Dr. Tobias Colon Cleanse Review: Does It Work for Constipation? (2026)

Quick answer: Dr. Tobias Colon Cleanse for constipation is a 14-day dietary supplement combining herbal laxatives, fiber, aloe vera, a probiotic, licorice root, and MCT oil: specifically, two stimulant laxatives (senna leaf and cascara sagrada), two fibers (psyllium husk and flaxseed), aloe vera gel, a probiotic strain (Lactobacillus acidophilus), licorice root, and MCT oil. Because it contains stimulant laxatives, it may stimulate a bowel movement within hours, though individual responses vary and there is no published clinical trial on this specific product. Among its ingredients, senna has the strongest direct evidence for constipation.^1,2

 

Cascara sagrada does not have that same backing. The FDA determined in 2002 that cascara sagrada was not generally recognized as safe and effective for OTC laxative use, meaning it could not be marketed as an OTC laxative drug ingredient without the required regulatory basis.³ Its presence here reflects the different regulatory framework that applies to dietary supplements compared with OTC drugs, which is worth knowing before you take it.

If you are reading Dr Tobias Colon Cleanse reviews because you are constipated, dealing with bloating, and looking for something that will actually move things along, this guide breaks the product down ingredient by ingredient, checks each one against the available research, and walks through dosage, what to expect, side effects, and who should stay away from it.

We will also look specifically at Dr Tobias Colon Cleanse for bloating and for constipation relief, since those are the two reasons most people pick this product up in the first place. It is written to be read alongside the label, not instead of it.

What Is Dr. Tobias Colon Cleanse?

Dr. Tobias Colon 14 Day Cleanse is a dietary supplement sold as a bottle of 28 vegetable capsules. At the time of writing it was priced around $19.99 on Amazon.⁴ Prices change constantly, so treat that figure as a snapshot and check the current listing before buying. It is one of the better known colon cleanse products in the U.S. market, and it shows up constantly in “best colon cleanse” roundups and Amazon best seller lists for detox and cleanse supplements.

Dr. Tobias Colon Cleanse Ingredients

The label lists eight active ingredients:^4,5

• Senna leaf
• Cascara sagrada bark
• Psyllium husk powder
• Flaxseed powder
• Aloe vera gel
• Lactobacillus acidophilus (probiotic)
• Licorice root
• Medium chain triglycerides (MCT) oil

Ingredient	Approx. amount per 2 capsule serving	Main role
Senna leaf extract	~285 mg	Stimulant laxative
Cascara sagrada bark	~300 mg	Stimulant laxative
Psyllium husk	~300 mg	Fiber
Flaxseed	~100 mg	Fiber
Aloe vera gel	~80 mg	Herbal ingredient
Lactobacillus acidophilus	~50 mg	Probiotic
Licorice root extract	~50 mg	Supporting ingredient
MCT oil	~14 mg	Supporting ingredient

These amounts are based on the current Dr. Tobias Supplement Facts panel and are listed per 2-capsule serving. Some ingredient amounts, including licorice root extract, have varied across different label records and product versions we reviewed, so the figures above should be treated as reflecting the label/version reviewed rather than a fixed constant. Formulations can change between production runs, so check the supplement facts panel on the bottle you receive before using the product.

That is a mix of two stimulant laxatives, two fiber sources, a probiotic strain, and a couple of supporting ingredients. It is a genuinely different formula from something like our Senokot review, which covers a single ingredient (senna) in isolation. Here, several mechanisms are stacked together, which makes the “does it work” question a little more complicated to answer honestly.

It is worth being precise about what that means. We could not identify a published randomized clinical trial evaluating the complete Dr. Tobias Colon Cleanse formulation. Its constipation effect is biologically plausible because it contains senna and cascara sagrada (stimulant laxatives) plus psyllium husk and flaxseed (fiber), and each of those ingredient categories has been studied on its own. But the complete formulation, as a single product, does not carry the same clinical evidence as individual, well studied laxatives like PEG or senna alone.

There is also no good clinical evidence that a colon cleanse is needed to remove “toxins” or accumulated waste from a normally functioning colon; any benefit here is best understood as relief from constipation itself, not a detox effect.¹⁵ That distinction matters if you are deciding between this and a single ingredient option.

Does Dr. Tobias Colon Cleanse for Constipation Actually Work? What the Research Shows

The honest answer is that it depends on which ingredient is doing the work, because the eight ingredients in this formula are not equally well studied. Among them, senna has the strongest direct clinical evidence for constipation, and psyllium husk is the best studied fiber. Flaxseed and probiotics have smaller but real trial support. Cascara sagrada does not carry current FDA recognition as a safe and effective OTC laxative ingredient. And aloe vera carries a safety flag that is worth understanding rather than ignoring.

Senna Leaf: The Strongest Evidence in the Formula

Senna is a plant derived stimulant laxative. Its active compounds, sennosides, are converted by colonic bacteria into metabolites that stimulate intestinal motility, which is why it tends to work within hours rather than days.²

The 2023 joint clinical practice guideline from the American Gastroenterological Association and American College of Gastroenterology gives senna a conditional recommendation for chronic idiopathic constipation, rating the certainty of evidence as low, a more cautious rating than the guideline gives to polyethylene glycol (PEG).¹

A separate 2021 systematic review of over the counter constipation remedies rated senna as Grade A within its own framework, placing it among the better supported OTC options.⁶ We cover this ingredient in far more depth, including dosing and side effects by product, in our full Senokot for constipation review.

Cascara Sagrada Bark: Not FDA Recognized as Safe and Effective

This is the ingredient most colon cleanse marketing glosses over, and it deserves more attention than it usually gets. Cascara sagrada is also a stimulant laxative, working through anthraquinone compounds that trigger intestinal contractions in a similar way to senna. But unlike senna, cascara sagrada does not have current FDA backing as a safe and effective OTC laxative ingredient.

The FDA determined in 2002 that cascara sagrada, used as a stimulant laxative, was not generally recognized as safe and effective for OTC laxative drug products, after requested safety data were not submitted.³ This meant the ingredient could not be marketed as an OTC laxative drug ingredient without the required regulatory basis.

Its presence in a dietary supplement like this one reflects the different regulatory framework that applies to supplements compared with OTC drug products in the United States, rather than a loophole. That is a genuine regulatory nuance worth knowing before assuming this ingredient carries the same government backing that senna does.

Psyllium Husk: One of the Best Studied Fibers for Constipation

Psyllium husk is a soluble, gel forming fiber from the seeds of Plantago ovata. It works by absorbing water and adding bulk to stool, and it is the same active ingredient found in Metamucil. A 2025 clinical review described psyllium husk as the gold standard fiber for regulating bowel movements, citing evidence for its effectiveness in both constipation and diarrhea through its gel forming properties.⁷

A Gastroenterology publication has separately discussed evidence that psyllium may favorably influence gut microbiota composition and reduce gut inflammation, beyond its simple bulking effect.⁸

However, the 300 mg of psyllium per 2-capsule serving is much lower than the gram-level doses commonly studied for constipation, so evidence for psyllium itself should not be interpreted as proof that the amount in this product will produce the same effect. The catch is that psyllium husk needs adequate water to work properly and comfortably, something worth keeping in mind given how much else is going on in this formula.

Flaxseed: Smaller Trials, Genuinely Promising Results

Flaxseed contributes both soluble and insoluble fiber. A randomized, placebo controlled trial in 53 constipated patients with type 2 diabetes found that 20 grams of flaxseed per day (given as 10 g twice daily) for 12 weeks significantly improved constipation symptom scores compared with placebo, alongside improvements in weight and lipid markers.⁹

Importantly, the trial used 20 g of flaxseed per day, whereas this product provides only 100 mg per 2-capsule serving, so those results cannot be directly extrapolated to the dose in Dr. Tobias Colon Cleanse. It is a relatively small trial in a specific patient population, so treat it as encouraging rather than definitive, but it is real controlled evidence, which is more than many “detox” ingredients can claim.

Aloe Vera Gel: A Safety Flag Worth Understanding

The FDA determined in 2002 that aloe ingredients, used as stimulant laxatives, were not generally recognized as safe and effective for OTC laxative drug products, for the same reason as cascara sagrada: insufficient safety data submitted by manufacturers.³

Separately, in 2013 the U.S. National Toxicology Program published a two year drinking water study in rats and mice using a nondecolorized whole leaf extract of Aloe vera, and found clear evidence of intestinal tumor activity in male rats.¹⁰ Based largely on that data, the International Agency for Research on Cancer (IARC) classified “Aloe vera, whole leaf extract” as Group 2B, meaning possibly carcinogenic to humans.¹¹

Some important context before this sounds scarier than it should. Importantly, this IARC classification applies specifically to Aloe vera whole-leaf extract, not to every form of aloe vera gel. The IARC classification specifically applies to non-decolorized whole leaf extract, which contains higher levels of anthraquinone compounds (found in the outer leaf latex) than the aloe vera gel or decolorized extracts commonly used in supplements and food products.^11,12

Dr. Tobias lists aloe vera gel as a 200:1 concentrated leaf powder. However, the exact anthraquinone or aloin content and processing characteristics of this ingredient could not be independently verified from the public product information. Given that ambiguity, it is a reasonable thing to ask about if you plan to use this product regularly rather than for one occasional cleanse, and it is one more reason label directions about limiting how often you repeat the cleanse are worth following exactly.

Probiotics, Licorice Root, and MCT Oil

Lactobacillus acidophilus is a well studied probiotic species in general, but probiotic effects are strain and dose specific, so evidence for probiotics as a category cannot automatically be applied to the specific strain and dose used in this product. The label reports 50 mg of Lactobacillus acidophilus, but a CFU count is more informative than milligram weight for evaluating probiotic dose. Without a clearly stated CFU amount and strain designation, the constipation evidence for probiotics cannot be meaningfully applied to this product.

A 2024 systematic review and meta-analysis of probiotics for constipation found some benefit across the pooled trials, though the authors noted substantial variation between the strains, doses, and study quality included (heterogeneity was high across the pooled studies), which is a common limitation across probiotic research generally.¹³

For a broader look at which strains have the most support, our guide to probiotic strains for constipation goes into more detail. Licorice root and MCT oil are included in smaller amounts and are not typically studied as constipation treatments on their own; they appear to function as supporting ingredients rather than primary actives in this formula.

Licorice root in particular is worth flagging separately: a systematic review and meta-analysis found that chronic licorice ingestion has been associated with increased blood pressure and lower potassium levels, particularly with products providing glycyrrhizic acid.¹⁴

The 50 mg per serving in this product is licorice root extract, not necessarily 50 mg of glycyrrhizic acid specifically, and the two should not be conflated; still, it is not an ingredient to take casually or in large amounts over long periods.

How to Use Dr. Tobias Colon Cleanse for Constipation

The current manufacturer directions describe a structured cycle across the full 14 days, with the capsules themselves used for only the first half. The table below reflects a practical way to follow the manufacturer’s directions (1 to 2 capsules at bedtime, for up to 7 consecutive days, starting at 1 capsule for first-time users); check the exact wording on your bottle, since minor phrasing can differ between label versions:^4,5

Phase	Directions
Days 1 to 4 (first-time users)	Start with 1 capsule at bedtime with 8 ounces of water.
Days 5 to 7	If needed, increase to 2 capsules at bedtime. Do not take capsules for more than 7 consecutive days.
Days 8 to 14	Stop the capsules. Continue with additional dietary fiber and water.
Between cleanses	Do not repeat the cleansing program for at least 6 to 8 weeks.

The capsule-free second week is easy to miss if you are skimming the label, but it is an important part of the protocol: the fiber and water phase is meant to let the digestive system continue regulating without ongoing exposure to the stimulant laxative ingredients.

Taking it at bedtime during the active week is a deliberate choice, since senna generally produces a bowel movement within roughly 6 to 12 hours, which lines up with a next morning result if taken before sleep.²

Because psyllium husk and flaxseed are also in the formula, drinking plenty of water throughout the day, not just with the capsules, matters more here than it would with a stimulant laxative alone. Because the formula contains psyllium, take it with the full recommended amount of water; insufficient liquid with a psyllium containing product can increase the risk of swallowing difficulty or choking, and the product should not be used by anyone who has trouble swallowing.

What to Expect During the 14 Day Cleanse

Based on the ingredients and the manufacturer’s own guidance, a fairly predictable pattern is commonly reported, though this is general guidance rather than data from a trial on this specific product:^4,5

• Days 1 to 7 (active phase): Bowel activity may increase during this window, largely because the formula contains stimulant laxatives, though there is no published trial data on this specific product to say how most users typically respond. Starting at 1 capsule rather than 2 reduces the odds of significant cramping during this phase. Mild cramping, gas, and looser stools may occur during the active phase because the formula contains stimulant laxatives and fiber. Severe or persistent abdominal pain, vomiting, rectal bleeding, or inability to pass stool or gas warrants medical evaluation.
• Days 8 to 14 (fiber and water phase): No more capsules. Some people notice constipation related bloating easing as bowel movements normalize, though the fiber ingredients can themselves cause gas or bloating in some people, especially if fiber and water intake increase quickly.

If you want a simple way to track whether your stool is actually normalizing during and after the cleanse rather than just guessing, our Bristol Stool Chart guide is a quick, free reference.

Side Effects

Potential side effects, consistent with what you would expect from a combination of stimulant laxatives and fiber, include:^1,2,4

• Abdominal cramping, especially at the full 2 capsule dose
• Bloating and gas
• Loose stools or diarrhea
• Nausea in some users
• Difficulty swallowing or a choking sensation if the capsules are taken without enough liquid, given the psyllium content

These effects are consistent with the known effects of stimulant laxatives and fiber, although individual responses vary; there is no published trial on the complete Dr. Tobias formulation to confirm how often or how quickly they resolve. If cramping is severe, or if you experience rectal bleeding or an inability to pass stool or gas, stop use and speak with a doctor rather than continuing or increasing the dose.

Who Should Avoid Dr. Tobias Colon Cleanse

This general list draws on typical warnings for stimulant-laxative and psyllium-containing supplements; always confirm against the current bottle’s actual label, which generally includes:^4,5

• Children and adolescents should not use this product unless specifically advised by a healthcare professional
• Anyone who is pregnant or breastfeeding
• Anyone currently experiencing abdominal pain, or diarrhea and loose stools, since stimulant laxatives can worsen these symptoms
• Anyone with difficulty swallowing, given the psyllium content and the associated choking risk without adequate liquid
• Because this formula contains stimulant laxatives and psyllium, people with known gastrointestinal disorders, including inflammatory bowel disease, diverticular disease, or possible bowel obstruction, should consult a healthcare professional before use
• Anyone with high blood pressure, low potassium, heart or kidney problems, or other conditions that may be affected by licorice should discuss the product with a healthcare professional before use¹⁴
• Anyone taking prescription medications, since fiber can affect the absorption timing of other drugs and stimulant laxatives can interact with certain medications
• Anyone experiencing a sudden, unexplained change in bowel habits lasting more than two weeks, or rectal bleeding, since these warrant medical evaluation rather than a cleanse

Always check the warnings on the current bottle, since exact contraindication wording can be updated by the manufacturer over time.

Dr Tobias Colon Cleanse vs Other Constipation Options

It helps to see where this product sits relative to more narrowly targeted options. If your main goal is simply relieving occasional constipation rather than a broader “cleanse,” a single ingredient product may be easier to dose predictably and easier to reason about in terms of evidence.

Option	Main mechanism	Best fit
Dr. Tobias Colon Cleanse	Stimulant laxatives + fiber + probiotic, combined	People seeking a short-term, multi-ingredient constipation/cleanse product
Senokot	Senna (stimulant) only	A precisely dosed, single ingredient stimulant laxative
PEG (MiraLAX and similar)	Osmotic, draws water into the colon	Recurring or chronic constipation; PEG has a strong recommendation in the AGA/ACG guideline
Natural laxative foods	Varies by food	Gentle, food first approach without a supplement

For a broader side by side look at where fiber, stimulant, and osmotic laxatives fit relative to each other, our best OTC laxatives guide covers the full lineup, and our magnesium supplements guide covers a different osmotic option entirely.

If you already have general fiber and probiotic support in your routine and are looking specifically at whether a probiotic supplement adds anything on top, our probiotics for constipation and bloating guide is the better next read.

Dr. Tobias Colon Cleanse Review: Our Verdict

To be direct about the central question: we could not identify a published randomized clinical trial evaluating Dr. Tobias Colon Cleanse as a complete formulation, so its effectiveness as a product cannot be considered clinically established.

Its likely effect on constipation is biologically plausible and reasonably well explained by two of its eight ingredients, senna and cascara sagrada (both stimulant laxatives), with psyllium husk and flaxseed contributing fiber on top of that.

But the complete Dr. Tobias formulation itself does not carry the same clinical evidence as individual, well studied laxatives like PEG or senna used alone.

Pros:

• Contains senna, an ingredient with genuine clinical trial support for constipation^1,6
• Also contains psyllium husk, one of the best studied fiber supplements for constipation and bowel regulation⁷
• Structured protocol with clear start and stop points (7 days of capsules, then a capsule free fiber and water week), rather than open ended daily use
• Widely available and reasonably priced at around $20 per cycle. The manufacturer states the product is tested for purity, potency, and authenticity and made in a GMP compliant facility, though we could not independently confirm the specific third party testing claims from public sources⁴

Cons:

• Contains cascara sagrada, which the FDA does not recognize as safe and effective for OTC laxative use³
• Contains aloe vera; the FDA also excluded aloe used as a stimulant laxative from OTC laxative drug products, and a related whole leaf extract form carries an IARC carcinogenicity classification, though the exact form used in this product’s aloe vera gel was not independently verifiable from public sources^3,10,11
• Combining eight active ingredients makes it harder to know which one is responsible for any given effect or side effect, and the product as a whole has not been clinically studied
• Not intended for repeated, frequent, or long term use

Where does that leave Dr Tobias Colon Cleanse for constipation? If you want an occasional, structured product and you understand the limitations of a multi-ingredient formula that we could not find evaluated in a published clinical trial, it may be an option for occasional short-term use for some adults who understand the product’s limitations and can safely follow the label directions, largely on the strength of its senna and psyllium husk content.

However, a single-ingredient option such as senna alone, or a guideline-supported option such as PEG, offers a clearer evidence and dosing profile if predictability matters more to you than a structured multi-step cleanse.¹ Either way, this is a short term tool for occasional constipation, not a long term management plan, and if you are reaching for something like this often, that pattern is worth mentioning to a doctor.

Frequently Asked Questions

Does Dr. Tobias Colon Cleanse actually work for constipation?

Because it contains stimulant laxatives (senna and cascara sagrada), it can stimulate a bowel movement, although individual response varies, and we could not identify a published clinical trial evaluating the complete product. Senna has clinical evidence supporting its use for constipation.^1,6 Cascara sagrada does not carry the same FDA recognition, so part of the formula’s likely effect comes from a well supported ingredient and part from one the FDA has specifically excluded from OTC laxative drug products.³

How long does it take for Dr. Tobias Colon Cleanse to work?

Because the product contains stimulant laxatives, bowel activity may occur within several hours. Senna specifically commonly produces an effect within about 6 to 12 hours, though individual response varies with dose, hydration, and baseline bowel habits, and cascara sagrada’s onset is less well characterized in the clinical literature.²

Is Dr. Tobias Colon Cleanse for constipation safe to use?

The product is labeled for adults, but safety depends on the individual and the reason for use, not a blanket assumption that it suits everyone who follows the label directions. It is not recommended for children, during pregnancy or breastfeeding, for people with a known gastrointestinal condition such as inflammatory bowel disease, current abdominal pain or diarrhea, difficulty swallowing, or alongside other medications, without checking with a doctor first, given the stimulant laxative, psyllium, and licorice root content.^3,14

Can I take Dr. Tobias Colon Cleanse every day long term?

No. The manufacturer’s own directions specify capsules for no more than 7 consecutive days, followed by a capsule free week, and a gap of at least 6 to 8 weeks before repeating the full cycle.^4,5 Daily, indefinite use of a stimulant laxative and aloe vera containing product is not what the label supports, and it is not something we would recommend without direct medical guidance.

What is the difference between Dr. Tobias Colon Cleanse and a single ingredient laxative like Senokot?

Senokot contains one active ingredient (senna, alone or paired with docusate sodium), which makes its dosing and evidence base straightforward to evaluate. Dr. Tobias Colon Cleanse combines eight ingredients with different levels of evidence and different regulatory statuses, and we could not identify a published clinical trial evaluating the complete formulation, which can make it harder to isolate what is working, or what might be causing a particular side effect. See our full Senokot review for the single ingredient comparison.

Does Dr. Tobias Colon Cleanse help with bloating?

Some people may notice temporary relief from constipation related bloating once bowel movements increase, which is plausible given the stimulant laxative and fiber ingredients, though we could not identify a published clinical trial evaluating the complete product for this specifically. The fiber ingredients can themselves cause gas or bloating in some people, especially when starting out.^7,8 A colon cleanse will not resolve bloating that is unrelated to constipation, such as bloating from food intolerances or small intestinal bacterial overgrowth.

Will Dr. Tobias Colon Cleanse for constipation give me a bowel movement right away?

Because the product contains stimulant laxatives, bowel activity may occur within hours. Senna specifically is typically associated with the 6 to 12 hour range, though individual response varies.² That is why the label directs you to take it at bedtime rather than in the morning.

When to See a Doctor

Stop using this product and speak with a healthcare professional if you experience any of the following:

• Severe abdominal pain, bloating, or vomiting
• Rectal bleeding or blood in the stool
• An inability to pass stool or gas
• A sudden, unexplained change in bowel habits that lasts more than two weeks
• Unexplained weight loss

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This article is for informational purposes only and is not a substitute for professional medical advice. Always read the current product label, since ingredient sourcing and formulations can change, and consult a doctor or pharmacist before starting a new supplement, especially if you are pregnant, breastfeeding, managing a chronic condition, or taking other medications.

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Disclosure: This site may earn a commission from qualifying purchases made through Amazon links above, at no extra cost to you. Product prices, pack sizes, and formulations can change, so confirm the current listing before ordering. Check the current price of Dr. Tobias Colon 14 Day Cleanse on Amazon.

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References

1. Chang L, Chey WD, Imdad A, et al. American Gastroenterological Association-American College of Gastroenterology Clinical Practice Guideline: Pharmacological Management of Chronic Idiopathic Constipation. Gastroenterology. 2023;164(7):1086-1106. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC10542656/
2. Senna (oral route). Mayo Clinic. Available at: https://www.mayoclinic.org/drugs-supplements/senna-oral-route/description/drg-20406012
3. Status of Certain Additional Over-the-Counter Drug Category II and III Active Ingredients (Aloe and Cascara Sagrada). Federal Register, Food and Drug Administration. 2002;67(90):31125-31127. Available at: https://www.govinfo.gov/content/pkg/FR-2002-05-09/html/02-11510.htm
4. Dr. Tobias Colon Cleanse – Constipation Relief & Gut Health Support, 28 Capsules. Amazon product listing. Available at: https://www.amazon.com/dp/B00ISAPPLI
5. Colon Cleanse: What It Actually Does, What to Expect, and How to Do It Right. Dr. Tobias official blog. Available at: https://drtobias.com/blogs/dr-t-blog
6. Rao SSC, Brenner DM. Efficacy and Safety of Over-the-Counter Therapies for Chronic Constipation: An Updated Systematic Review. Am J Gastroenterol. 2021;116(6):1156-1181. Available at: https://pubmed.ncbi.nlm.nih.gov/33767108/
7. Psyllium Husk: Gold Standard Fiber for Bowel Regulation. PMC/NIH. 2025. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC12224249/
8. Psyllium Husk Alters Gut Microbiota, Reduces Inflammation, and Regulates Bowel Function. Gastroenterology/PubMed. 2024. Available at: https://pubmed.ncbi.nlm.nih.gov/37979710/
9. Soltanian N, Janghorbani M. A randomized trial of the effects of flaxseed to manage constipation, weight, glycemia, and lipids in constipated patients with type 2 diabetes. Nutr Metab (Lond). 2018;15:32. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC5944250/
10. Boudreau MD, Beland FA, Nichols JA, Pogribna M. Toxicology and carcinogenesis studies of a nondecolorized whole leaf extract of Aloe barbadensis Miller (Aloe vera) in F344/N rats and B6C3F1 mice (drinking water studies). National Toxicology Program Technical Report Series. 2013;577:1-266. Available at: https://ntp.niehs.nih.gov/go/tr577abs
11. Some Drugs and Herbal Products (Aloe vera). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 108. International Agency for Research on Cancer. 2016. Available at: https://publications.iarc.who.int
12. Aloe vera, non-decolorized whole leaf extract. Office of Environmental Health Hazard Assessment, California EPA. Available at: https://oehha.ca.gov/chemicals/aloe-vera-whole-leaf-extract
13. Effectiveness of Probiotics in Patients With Constipation: A Systematic Review and Meta-Analysis. PMC. 2024. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC10854359/
14. Penninkilampi R, Eslick EM, Eslick GD. The association between consistent licorice ingestion, hypertension and hypokalaemia: a systematic review and meta-analysis. J Hum Hypertens. 2017;31(11):699-707. Available at: https://pubmed.ncbi.nlm.nih.gov/28660884/
15. “Detoxes” and “Cleanses”: What You Need To Know. National Center for Complementary and Integrative Health (NCCIH), National Institutes of Health. Available at: https://www.nccih.nih.gov/health/detoxes-and-cleanses-what-you-need-to-know